GE Analytical Instruments

The Sievers 500 RL On-Line Total Organic Carbon (TOC) Analyzer from GE Analytical Instruments is a reagentless analyzer designed for continuous monitoring of organics in ultrapure water for pharmaceutical and other applications. The Sievers 500 RL provides superior analytical accuracy and performance, according to GE, with a 0.03 ppb limit of detection and autozero capabilities. The 500 RL TOC Analyzer provides a range of options that can be customized to meet the specific needs of a wide variety of applications.

Designed for Real-time Water Release

The Sievers 500 RL On-Line TOC Analyzer is designed to deliver science-based risk management capability to the production floor. This is largely achieved by integrating the trusted Sievers laboratory TOC analysis methodology into a reagentless on-line analyzer that delivers the same high level of analytical process capability associated with laboratory analyzers, but without the delay. The 500 RL thus supports pharmaceutical industry quality initiatives such as Process Analytical Technology (PAT) and on-line Cleaning Validation (CV).

Main Configurations

The 500 RL has three main configurations which relate to the type of standards introduction device offered, and each can be upgraded with a variety of options:

  • 500 RL with Super iOS
  • 500 RL with standard iOS
  • 500 RL base model

The new Super iOS (Integrated On-Line Sampling System) is a four-port system that fully automates system protocols, including system suitability, significantly reducing operator time, risks, and costs. The Super iOS can also run single standards and grab samples, like the standard iOS.

Technology

The 500 RL On-Line TOC Analyzer utilizes the patented Sievers membrane conductometric technology, which eliminates false positive and false negative readings to which other technologies are susceptible. Additionally, the Sievers' technology ensures accurate recovery of all classes of organic compounds commonly found in UPW waters.

Ease of Use Features

The Sievers 500 RL includes a large color touch-screen display, intuitive menu interface, on-screen consumables status indicators, and automated system protocols, such as system suitability verification.

Regulatory Compliance

The Analyzer complies with USEPA-approved Standards Methods 5310C and the proposed USEPA 415.3 for regulatory monitoring. It also complies with ASTM-approved methodologies, and provides security consistent with 21 CFR Part 11.

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Category:
Process Control
Product Type:
Process control
Manufacturer:
GE Analytical Instruments