Small Molecule

AstraZeneca, Pharmacyclics Announce Immuno-Oncology Clinical Trial Collaboration

Nov 04, 2014

AstraZeneca and Pharmacyclics Inc. have entered into a clinical trial collaboration to evaluate a novel combination therapy targeting solid tumors.

The collaboration will evaluate the efficacy and safety of Imbruvica (ibrutinib), Pharmacyclics' oral Bruton's tyrosine kinase inhibitor, in combination with AstraZeneca's anti-PD-L1 antibody, MEDI4736. According to a press release, preclinical evidence suggests that the combination of Imbruvica with this investigational medicine may enhance their effects. The results of the clinical studies will be used to determine whether further clinical development of the different combinations is warranted.

"We are extremely interested in the potential for IMBRUVICA in combination with an anti-PD-L1 antibody to improve the treatment of solid tumors in patients who need better therapeutic options," said Bob Duggan, chairman & CEO, Pharmacyclics.

Imbruvica is being developed and commercialized by Pharmacyclics and Janssen Biotech Inc. Read the full release