Automation & Control

Multivariate Calibration: A Science-Based Method - Part 2

Science-based calibration (SBC) mechanizes the calibration process by removing choices and by forcing the user to substantiate each of the inputs with scientific backup information

By Ralf Marbach, VTT Optical Instruments Center

Editor’s Note: In Part 1 of this article (Pharmaceutical Manufacturing, January 2007, p. 42), the author introduced science-based calibration (SBC), providing some theoretical background, a summary of the method, an example of its use and a discussion of its advantages. In Part 2, Marbach focuses on the method’s applicability and limitations, as well as the specificity of response.

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