ChromaSorb Anion Membrane Chromatography Solution
Millipore Corporation, a Life Science leader providing technologies, tools and services for bioscience research and biopharmaceutical manufacturing, announces its new single-use ChromaSorb membrane adsorber.
ChromaSorb devices bind negative impurities from host cell protein (HCP), DNA, endotoxins, and viruses at salt concentrations well above those of traditional resins and membranes. The breakthrough technology behind the ChromaSorb solution enables these devices to function at a wide range of salt concentrations, eliminating the need to dilute feedstreams prior to processing. This unique ability avoids the downstream bottleneck of buffer tank capacity that is inherent to competitive disposable adsorbers at the polishing step.
“Millipore continues to respond to the biomanufacturing industry and our customers’ needs by launching the ChromaSorb solution – a disposable alternative for the polishing step. Disposables remove the high upfront capital costs of biomanufacturing hardware such as columns, chromatography systems, and buffer tanks, and significantly reduce validation requirements, labor and overhead,“ according to Paul Chapman, Millipore’s vice president, Downstream Processing.
The ChromaSorb solution is comprised of a linearly scalable family of devices. The ChromaSorb 0.08 mL process development device requires a third less volume of feedstock than other membrane adsorbers, allowing for the design of robust experiments. ChromaSorb 0.08 mL devices for process development, optimization and scale up are currently available; ChromaSorb 50 mL and 500 mL devices will be available soon.