Displaying 1–25 of 36 results for Unit Operations

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Clean in Place Operations for Thin-Cake Filtration Operations

(Whitepaper)

In many chemical and pharmaceutical processes, solid-liquid separation, cake washing and drying steps directly impact the effectiveness of the production operation. In solid-liquid separation, there is a choice both of the type of filter media and the thickness of the cake or the cake depth ...

Calculating Total Uncertainty of Temperature Calibration with a Dry Block

(Whitepaper)

This article will discuss the various uncertainty components related to temperature calibration using a temperature dry-block. Also, it will discuss how to calculate the total uncertainty of a calibration performed with a dry block.

eBook: Solid Dose Spotlight

(Whitepaper)

Seeking Agile, Excellent Oral Solid Dose Operations

Using a Coriolis Flowmeter's Multivariable Characteristics to Validate ...

(Whitepaper)

The most common maintenance operation for any flow metering technology is focused around validating the device's calibrations stability over time. This document describes a procedure that uses the multivariable capabilities of a Micro Motion Coriolis flowmeter to provide an in-situ validation of ...

Turning Data Into Information: Making Sense of an Avalanche of Supply Chain ...

(Whitepaper)

Biomanufacturing and operations research experts describe how to deal with staggering volumes of production and supply chain data. Learn how to convert this data into actionable information, which will be of value to the whole organization. Read about consolidating data from disparate sources, ...

Recovering Precious Metals from Spent Catalysts

(Whitepaper)

Looking for a new revenue stream? Recycling catalysts is easy and profitable — and so overlooked — as Sabin Metals explains.

Plastic Towers Help Manufacturers Keep Their Cool

(Whitepaper)

Plastic cooling towers are increasingly replacing metal towers in many industries. This paper is designed to help engineers understand how plastic towers' durability is helping reduce maintenance costs and avoid costly interruption due to tower failure.

Use CFD to Improve Crystallization

(Whitepaper)

Drug manufacturers charged with developing, scaling up or scaling down any process involving crystallization face major challenges, given the industry's current understanding of flow characteristics and crystallization kinetics. In this article, Kumar Dhanasekharan, Ph.D., technical specialist ...

Maximizing the Benefits of PEGylation by Optimizing the Conjugation Process

(Whitepaper)

PEGylation can improve product yields, adding significant value.

The Next Wave in Disposable Mixing

(Whitepaper)

Disposable mixers have expanded their repertoire and can now handle high-viscosity solid/liquid mixing. Wave Biotech maps out the throwaway future.

Applications Note on Multipurpose Peeler Centrifuges

(Whitepaper)

The latest generation of multipurpose GMP-compliant peeler centrifuges have been designed to ease batch changes, prevent contamination and improve separation. This applications note from Riera Nadeu U.S.A. discusses considerations for specifying, cleaning and using this type of equipment.

Preventing Segregation During Powder Drying

(Whitepaper)

This case history by Jeroen van den Berg of Bolz-Summix discusses how changing process conditions within a conical screw dryer eliminated granulation and minimized product segregation.

NIR and Imaging: Basic Principles and Pharmaceutical Applications

(Whitepaper)

This article by Gabriele Reich at the University of Heidelberg's Institute for Pharmaceutical and Molecular Biology examines the basics of NIR spectroscopy.

Phase Transformation in Solid Pharmaceutical Materials

(Whitepaper)

This 72-page PDF, a dissertation by Denny Mahlin at Sweden's Uppsala Faculty of Pharmacy, discusses results of using atomic force microscopy and other techniques to study solid mixtures for solid dosage forms.

Best Practices for Materials Handling for Primary and Secondary Pharmaceuticals

(Whitepaper)

This 8-page paper by GEA Pharma Systems provides a timeless summary of specifications and selection criteria, with regard to materials handling and containment.

Cellulosic Esters: Compression Behavior and Film Coating Properties

(Whitepaper)

This 48-page thesis by Hong Xia Guo at Helsinki University looks at the impact of compression and the enteric coating properties of cellulose esters.

Aqueous Film Coating of Tablets in a Side-Vented Pan Coater

(Whitepaper)

This 53-page thesis by Mirja Ruotsalainen at Helsinki University, Finland, examines the impact of coating and storage on surface morphology, moisture control and stability.

Process Modeling and Control Challenges in the Pharmaceutical Industry

(Whitepaper)

In this 2003 presentation made at a conference held by the University of Texas, Phil Dell'Orco, GSK's Leader for Process Safety and Design, summarized the challenges facing engineers as they work to improve control of pharmaceutical processes in an industry still dominated by chemists.

Assessment of Risk Factors in Container-Closure Systems

(Whitepaper)

This paper looks at applying Process Analytical Technologies to the lyophilization process to mitigate risk factors that could lead to producing a poor product. Dr. Jennings argues that risk can be lowered by increasing the number of samples, thereby raising the confidence level and reducing the ...

AstraZeneca Decided for Paperless Solution

(Whitepaper)

AstraZeneca opted for a paperless solution that would allow for data trending and a centralized, accessible calibration data base. It is cost effective.

Single, Straight-Tube Coriolis Sensors: Installation Best Practices for ...

(Whitepaper)

Biopharmaceutical manufacturing is performed in a highly sterile environment. Bioreactions take place over an extended period of time. For example, it can take 6-8 weeks to complete a single bioreactor batch. Given the time that is committed to manufacturing biopharmaceuticals and their market ...

Reduce Contamination Risk with Advanced Local User Notification Indicators ...

(Whitepaper)

During continuous particle monitoring of a cleanroom environment, a meaningful user notification system near the point of sampling is an important factor in successful intervention and root cause analysis of particle events. Though many remote optical air particle counter suppliers feature a ...

Complying With U.S. FDA Title 21 CFR Part 11 for the Life Sciences Industry

(Whitepaper)

The purpose of this document is to describe the functions and features of SAP ERP that demonstrate technical compliance with U.S. FDA 21 CFR Part 11 Electronic Records; Electronic Signatures Final Rule and several international good manufacturing practice (GMP) guidelines having similar ...

Increasing Tablet Press Productivity Using Segmented Turret Technology

(Whitepaper)

Surveys of tablet press users reveal that machines with segmented turrets increase output and reduce set-up and cleaning time over conventional presses and previous turret technologies. This paper will discuss survey data from drug manufacturers using the technology and quantify some of the ...

Zeta Plus Activated Carbon Cartridges Evaluation & Scale-Up for ...

(Whitepaper)

This Technical Brief describes how the Zeta Plus Activated Carbon Cartridge series is evaluated for use in pharmaceutical applications and how the optimal carbon type and media grade are chosen for a given application. In addition, the brief describes how a process is scaled-up in order to ...

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