Technical papers on a range of topics, written by expert technology and equipment suppliers in the industry.
A right granulation method: Key for a successful tableting
A tableting of the blended powder formulation with or without granulation is an important cog of a tablet manufacturing chain. This decision dictates a transformation of the blended powder formulation into a robust tablet. The granulation step imparts the suitable powder bulkiness, flowability, and strength required for: an easy handling, a uniform dispensing from the hopper, and to confer the desired strength of the final tablet. Download now
This white paper is sponsored by Natoli.
Streamline Change Control
A broken and inefficient change control process increases compliance risk and delays product ship decisions. By unifying disconnected systems and processes you can build the foundation for change control transformation. By reading this white paper, you will learn how to:
- Connect people, processes, and technology
- Connect change control and variation management
- Enable supplier collaboration and visibility
This paper provides a holistic approach to streamlining the change control process to improve quality, compliance, and time-to-market. Download now
This white paper is sponsored by Veeva Systems Inc.
Improving therapy initiation with an AI-guided patient support program
There are many factors that can affect medication access and initiation. With the power of AI and predictive analytics, patient support interventions can be optimized to allow for a leaner and more effective program. Read about how one manufacturer improved therapy initiation by leveraging AI and predictive analytics. Download the case study. Download now
This white paper is sponsored by AmerisourceBergen-Lash Group.
Compressed Air Engineering Handbook
Producing compressed air can be expensive and merely having the knowledge of how to install and maintain compressors correctly is not enough. Plant managers, operators, and engineers must understand how compressed air integrates into the plant and how it can affects a plant’s bottom line. Learn how even small changes in a compressed air system can result in significant and tangible improvements in efficiency. Download now
This white paper is sponsored by Kaeser Compressors, Inc.
The role of vacuum technology in lyophilization
Vaccines, antibiotics, and sensitive biochemicals require delicate drying methods, such as lyophilization or freeze drying, to improve shelf life and storage conditions. Freeze drying or lyophilization can be done without the use of heat which may damage sensitive protein structures. This white paper reviews the four major components of lyophilization and the role of vacuum technology in the process. Download now
This white paper is sponsored by Busch Vacuum Solutions.
How to apply simulation and design in pharma
The Life Sciences Sector is experiencing an unprecedented change in the way new medicines and medical technologies are being developed. Increasingly, visionary companies in the sector are deploying modeling and simulation to reduce costs, mitigate risks and increase innovation.This white paper will cover a range of applications from medical device design to pharmaceutical manufacturing processes. We hope they will inspire you to make simulation an integral part of your design and manufacturing processes. Download now
This white paper is sponsored by Siemens.
How AI drives down production costs, extends equipment utilization and improves overall factory efficiency
Controlling costs and improving production efficiencies by embracing digital transformation has become a key strategy of pharmaceutical manufacturers in their attempts to maintain high quality, achieve profitability and mitigate risk. Consequently, the pharmaceutical manufacturing industry is welcoming new technologies, particularly in the area of advanced AI analytics and automation. These new technologies hold the key to greater manufacturing effectiveness in pharmaceutical manufacturing. Learn more about how AI predictive analytics can help pharmaceutical manufacturers of all sizes. Download now
This white paper is sponsored by BISTel.
How to ensure chemical inventory safety and compliance with regulations
When federal, state and local safety regulations concern chemicals, it is vital that the organization deploy efficient processes and systems to easily comply with the regulations, ensure safe chemical management, and produce accurate chemical inventory reports. This white paper discusses the obstacles organizations face ensuring chemical compliance and how different organizations have solved the compliance challenge. Download now
This white paper is sponsored by BIOVIA.
Better LOD and sulfated ashing techniques for pharmaceutical manufacturing
Extensive quality testing is normal within any pharma corporation. These testing methods should be safe, reliable, and accurate — but traditional techniques do not always meet these requirements. Fortunately, new ashing furnace and moisture analyzer technologies offer pharma manufacturers better options — and meet all LOD and muffle furnace requirements for global pharmacopeia. Download this white paper to learn how you can improve your company's proximate testing. Download now
This white paper is sponsored by CEM Corporation.
Intelligence-first approach to manage reliability in pharmaceuticals
Industry 4.0 tools can cut manufacturing costs by up to 20%, improve quality and increase flexibility while making deliveries more reliable. A solid, scalable reliability and maintenance strategy provides learning and value justification for tackling more difficult problems. Falkonry's experience from working with dozens of customers across hundreds of use cases is that an “intelligence-first” approach works best. They illustrate this approach in this e-book in further detail. Download now
This white paper is sponsored by Falkonry.
Increase vaccine efficacy and yield: how cryogenic cold-temperature solutions are providing increased value in the manufacturing, storage, and distribution of vaccines
Many vaccines and other pharmaceuticals, due to their biological instability, typically need to be kept at colder temperatures, sometimes as cold as -80⁰C (-112⁰F) and even down to -180⁰C (-292⁰F). There are a variety of cold-temperature processes allowing producers to overcome the challenges of manufacturing and scaling up these life-saving products. Learn how cryogenic cold-temperature solutions, using Liquid Nitrogen and Dry Ice (CO2), have been gaining favor over mechanical refrigeration methods throughout manufacturing, storage and distribution offering greater efficacy, stability and yield. Download now
This white paper is sponsored by Air Products.
Manufacturing sterile parenteral pharmaceuticals: how to protect oxygen-sensitive formulations
How well do you protect your oxygen sensitive formulations during filling? Many biopharmaceutical drug formulations have some degree of oxygen sensitivity. Monitoring the headspace gas composition of oxygen sensitive product during filling serves as an in-process control of the nitrogen purging and can help ensure that the product being produced will retain stability and efficacy. This e-book describes how to protect oxygen sensitive formulations, covering methods for in-process monitoring of oxygen, nitrogen purge optimization and validation, including nitrogen purge qualification and process development data of a manufacturing filling line. Download now
This white paper is sponsored by Lighthouse Instruments.
Case study: competing on quality & agility in the pharma industries
What does it take to make quality your competitive advantage? Comar knows the answer. Quality and agility are what differentiates them from their competition in medical, pharmaceutical, and healthcare packaging. Learn how real-time insights from the factory floor provides the intelligence Comar needs to:
- Make timely, informed decisions
- Reduce downtime and preventable breakdowns
- Build quality into their processes
- Document movement of raw materials and supplies
- Ensure the reliability and consistency of results for every customer
This case study is sponsored by Dassault Systemes America's DELMIAWorks.
Critical parameters for cleanroom monitoring
A comprehensive cleanroom monitoring strategy combines real-time data acquisition, analysis, and reporting to support validation and ongoing compliance efforts. Learn how your lab can ensure an optimal cleanroom environment and the safety of valuable scientific work in the white paper Critical Parameters for Cleanroom Monitoring. Download now
This white paper is sponsored by XiltriX.
Personalized medicine: biomanufacturing challenges – succeeding beyond the blockbuster
The traditional model for the pharmaceutical industry has focused on the development of blockbuster, broad-spectrum medicines that treat millions of patients globally. However, these medicines often do not work for large groups of patients and many diseases still lack effective treatments. This white paper outlines some of the research and production challenges and their attendant solutions. Download now
This white paper is sponsored by Watson-Marlow.
The manufacturing agenda for pharmaceutical packaging excellence
Today’s pharmaceutical manufacturers face significant pressure to speed time-to-market and adapt to rapid market changes, all while ensuring quality and regulatory compliance. The Manufacturing Agenda for Pharmaceutical Packaging whitepaper highlights key strategies to balance quality, compliance, and agility to achieve operational excellence. Download now
This white paper is sponsored by Dassault Systemes America's DELMIAWorks.
A study of the peristaltic life and pumping performance of three TPE tubing products to assess their suitability for continuous bioprocessing
This study reveals noteworthy results that affirm the need for drug manufacturers to consider the peristaltic life of all tubing products used in continuous bioprocessing. This paper details that samples of WMFTG PureWeld XL tubing were compared to two leading industry alternative SEBS TPE products to assess pumping performance over time and peristaltic life. Three tubing materials were selected, PureWeld® XL, Competitor A and Competitor C. Tubing size 6.4 mm bore by 2.4 mm wall was used in each test. For each test conducted there were five samples of each material. The testing was carried out on three Watson-Marlow 530Du drives fitted with 520R2 pumpheads. Download now
This report is sponsored by Watson-Marlow.
Case study: learn how one company added confidence to their routine decontamination
Saving time and resources is crucial for every pharmaceutical company when it comes to decontamination. This case study examines how a high-volume compounding facility integrated a STERIS VHP Biodecontamination System, the challenges encountered and the results achieved. Read more to learn how they automated and improved the efficacy of their decontamination process through STERIS VHP Integrated Systems. Download now
This report is sponsored by STERIS.
Choosing a reliable temperature control system in the pharmaceutical industry
When considering a temperature control system for medical processing, precision and accuracy are key. Mokon’s advanced solutions are relied on by medical, pharmaceutical and biotechnology companies to help accelerate COVID-19 vaccine production. Mokon’s advanced portable chillers, circulating water and combination heating and chilling solutions are used for vessels, mixers, fermenters and bioreactors to ensure effective temperature control. When choosing a solution for your critical application, system size, fluid, control features, installation and preventive maintenance play an important role. With these components in mind, you’ll be able to find a reliable temperature control system for your application. Download now
This report is sponsored by Mokon.
TOC in pharma
TOC (total organic carbon) is a key indicator for organic impurities. The determination of this parameter is therefore crucial to ensure the purity and quality of pharmaceutical products. TOC and TNb (total bound nitrogen) analysis are routine tasks but reliable results can be very challenging to achieve. Analytik-Jena presents simple and effective ways to address these routine challenges:
- Cleaning validation procedures
- TOC performance test
- TOC extractables testing according to USP <661>
- Total protein determination
- Analyzers and techniques
This white paper is sponsored by Analytik-Jena
Digitalization for pharmaceuticals: safeguarding product supply by ensuring asset and process health
In the pharma industry, equipment failures, changing operating conditions and other unexpected occurrences can cause batch failures, resulting in costly production losses and disruptions to supply. So how can companies maintain the security of supply while protecting profits? In this white paper, read examples of how pharmaceutical companies are turning to asset performance management to help them:
- Predict equipment breakdowns weeks in advance
- Ensure process consistency and drive greater product quality and yield
- Reduce CAPEX and extend the life of critical assets
This white paper is sponsored by AspenTech.
Dealing with time-consuming sample analyses during the fermentation process?
Nicro, a Croatian process engineering company, found a solution that eliminates the need for sampling all together. Combining their capabilities with Endress+Hauser and BIOCentre, they created a safe, in-line solution with real-time monitoring. Download now
This case study is sponsored by Endress+Hauser