Exelixis and collaborator Genentech, a member of the Roche Group, have filed a New Drug Application (NDA) with the FDA for a combination melanoma treatment.
The combination features cobimetinib, a specific MEK inhibitor discovered by Exelixis, and Roche's Zelboraf, already on the market.
According to FierceBiotech, in a Phase III study disclosed over the summer, the combination treatment helped subjects live significantly longer without tumor growth than those treated with Zelboraf alone. Patients treated with the combination reported a median progression-free survival of 9.9 months compared to 6.2 months on Zelboraf, the companies reported.
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