Understanding Modified Release Technologies

PAT-based analysis methodologies help see, quality and quantify subtle changes in dosage forms

By Emil W. Ciurczak, Contributing Editor

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There are numerous mechanisms for delivering a drug to a patient. Whether tablets or capsules, sublingual solid doses or patches, injectables or suppositories, when it comes to drug delivery solutions, all may be modified for time of API release into the bloodstream. Among these, tablet-based dosage forms have particular complexities which, depending on formulation, can grow exponentially — depending on the modified release (MR) strategy chosen to correctly administer the tablet’s therapeutic dose over time. Process analytical technologies (PAT), fortunately, can help drug makers better understand the choices they make and provide the data they need to better understand MR mechanisms relative to formulation and support a robust and effective QA/QC effort.

There are numerous definitions of MR. Modified release can be defined to mean any “un-natural” mechanisms used to change the bioavailability or rate of uptake of the API by a body. As a baseline, consider a mixture of API, excipients (bulking agents), lubricants and flow agents as the “natural” mode for tablets. That is, no chemical is added to modify the solubility of the API, in any manner. 

 

When a dosage form is modified, it may be to either speed up or slow down the release from the matrix (all the non-active ingredients). The nearest analogy may be a military missile: a standard tablet may be seen as a ballistic artillery shell; the modified dosage form is a guided missile. A number of popular approaches will be covered with suggested techniques that could be used (in a PAT program) to assure proper parameters.

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ACCELERATED API BIOAVAILABILITY

A number of APIs are known to have low or slow solubility in vivo. Physical and chemical modifications to both the API and matrix may be made to speed up the transport to the drug to the blood. One common approach is to keep the API in an amorphous state to aid in its solubility (Figure 1 shows the % crystallinity, followed through a blending process). In this case, a Raman or NIR scan during the granulation and pressing of the tablet can assure that the API was not converted to a more crystalline form.

Another approach is to add a solubilizing material, such as a surfactant, disintegrant or both. Again, a simple NIR approach may be used: a mere reflection spectrum to assure rations or chemical imaging to show distribution of materials.
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CONTROLLED RELEASE (DELAYED)
A number of drugs are administered around the clock to maintain effective blood levels. In the “classic” approach, a tablet or capsule may be administered three or four times a day. This assumes patient compliance and, while effective, blood level graphs may resemble a roller coaster ride. To assure more even blood levels, continuous release dosage forms have been developed.

 

Entero-Coated Tablets: available since the 1960s, these dosage forms depend on an insoluble matrix, usually something like carnauba wax, in which particles of API and soluble excipients, such as starch, are mixed and pressed into a tablet. As the starch dissolves, the solvent reaches the API and slowly dissolves the particles.

It was seen, as far back as the early 1970s, that the rate of release could be predicted through thermal analysis (DSC or DTA). The faster the matrix was cooled or the harder it was pressed into tablets, the higher the energy of the wax polymorph formed. The consequence of the high energy polymorph was greatly slowed dissolution. Today, Raman or NIR can easily monitor (and control) the polymorphic state. Some other MR approaches include:

 

Film Coating: The most common method has been to modify the type and thickness of the coating. The coating could be designed to dissolve at a set pH (as in the intestine @ 7.5 instead of the gut @ 1.0) or remain intact and allow drug and solvent to pass through in a controlled manner.

 

Raman or NIR may be used in situ in the coating pan to monitor the correct application of the coating material(s) to the cores in real time. After the coating and/or during development, Terahertz is useful to show, not only the thickness of the coating, but whether or not the coating is properly adhering to the core (Figure 2 shows NIR spectra of a core being coated).

 

Timed-Release Beads: Or, as commercials put it, “tiny little time pills.” These are usually inert cores, coated with drug, then coated with some coating material(s) (Figure 3, NIR chemical image of time release bead). The thickness of the coating determines the dose level and rate of release. Both NIR and Raman may be used in the spray pans or Wurster coater to control the coating profile.

 

Reservoir with Polymer Coating: This dosage form is, in essence, a liquid or semi-solid reservoir with a controlling polymer coating to control the release rate (Figure 4). Again, NIR or Raman as controls could allow real-time control.

 

Drug Dispersed in Polymer (with polymer coating): Figure 5 shows the similarity of this type to the two preceding types. However, mixing the drug with another polymer to give a controlled matrix allows the reproducibility to be somewhat better than the other two forms.

 

Bulk-Eroding and Surface Eroding Biodegradable Systems: Figure 6 shows the general form of these type of products. They are made from biodegradable (e.g., polylactate) matrices and can be ingested or placed subcutaneously for long-acting drug delivery. Once again, NIR and or Raman may be used for controlling the production of these forms.

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