ViiV Healthcare, global specialist HIV company majority-owned by GSK, announced positive findings from a small proof-of-concept study of its investigational, broadly neutralizing antibody (bNAb) in adults living with HIV.
bNAbs — antibodies that can recognize and block the entry of different strains of HIV into healthy cells — have the potential for dual action capabilities within HIV treatment and prevention. ViiV's investigational treatment, N6LS, is a bNAb that works by binding to a specific site on the surface of HIV that prevents its entry into immune system cells.
N6LS is being studied at two dosing levels – a high dose and ten-fold lower dose — in adults living with HIV. The 14-person phase 2a BANNER study showed that a single infusion of N6LS demonstrated strong antiviral efficacy at both doses while also being well-tolerated by study participants.
According to ViiV, these positive proof-of-concept findings show N6LS’s potential as a first-in-class treatment option and could lead to the development of ground-breaking medicines that can help change the way HIV is treated.
ViiV Healthcare expects to begin a phase 2b study of N6LS in combination with other anti-retrovirals in 2023 to further evaluate the efficacy, safety and tolerability. Future areas of study include its potential utility as a long-acting therapeutic option and in approaches for an HIV remission and cure.