Multivariate Calibration: A Science-Based Method - Part 1

An alternative approach uses physical methods to estimate the spectral signal and statistical methods to estimate noise.

By Ralf Marbach, VTT Optical Instruments Center

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Editor’s Note: In Part 1 of this article, the author introduces science-based calibration (SBC) and provides some theoretical background, a summary of the method, an example of its use and a discussion of its advantages. In Part 2 (Pharmaceutical Manufacturing, February 2007, p. 44), Marbach will focus on the method’s applicability and limitations, as well as the specificity of response.

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