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Multivariate Calibration: A Science-Based Method - Part 2

By Ralf Marbach, VTT Optical Instruments Center

PharmaManufacturing.com

Science-based calibration (SBC) mechanizes the calibration process by removing choices and by forcing the user to substantiate each of the inputs with scientific backup information

Editor’s Note: In Part 1 of this article (Pharmaceutical Manufacturing, January 2007, p. 42), the author introduced science-based calibration (SBC), providing some theoretical background, a summary of the method, an example of its use and a discussion of its advantages. In Part 2, Marbach focuses on the method’s applicability and limitations, as well as the specificity of response.

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