On Solid Ground: Pharma’s Most Mature Dosage Form Endures

Oral solid dose manufacturers may not be reinventing the wheel – but they are fine-tuning it

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Looking back on the history of the pharmaceutical industry, it’s very much an evolving practice, with new knowledge bringing continuous improvements. Copious trial and error has brought us an industry very different from that of 150 years ago. And yet, one methodology has survived the decades essentially intact. The basic oral solid dose manufacturing methodology used today is very similar to the OSD manufacturing of the past — and that’s not necessarily a bad thing. In 1843, British painter/author/inventor William Brockedon patented an invention that compressed sodium carbonate and potassium carbonate in a tube, to form solid tablets. Eliminating the need for…

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