Sartorius North America Inc.

In modern biotech manufacturing, it is now common to produce a wide range of proteins using genetically manipulated microorganisms or animal cells. However, the efficiency of traditional, small-scale laboratory production systems (i.e. shaking flasks, T-bottles or spinner flasks) has been limited because oxygen input is low and pH levels cannot be controlled. Also, standard bioreactors and fermentors historically have had a relatively high initial investment cost, especially those with in-built control of temperature, agitation speed, dissolved oxygen, pH and foam or level in a reactor vessel.

Sartorius has introduced Biostat Aplus, a range of compact, autoclaveable bioreactor/fermentor systems with working volumes of up to 5 liters. These systems are affordable to users with limited budgets, which has been facilitated by transferring the controlling “Human-Machine Interface” to a standard notebook PC. This concept has the additional benefit of enabling the user to operate the system and transfer measured data to an additionally installed MFCS/DA SCADA software package for further evaluation.

Further cost savings have been realized by developing application-specific configurations for both microbial and animal cell cultivation. These configurations are available with a choice of 1-, 2- or 5-liter working volume vessels as well as optional add-ons and weight measurement. Each system is supplied with detailed information guides describing recommended experimental conditions, media composition, controller set points, etc. for the most commonly encountered expressions systems.

Process Control
Product Type:
Process control
Sartorius North America