Enhanced mAb Aggregate Removal with Mixed-Mode Chromatography

Monoclonal antibodies (mAbs) are powerful therapeutics that are clinically trusted and well-characterized.  However, their production can be complicated by difficult-to-remove aggregates and impurities.

In this application note, you’ll learn more about how a mixed-mode chromatography tool designed to tackle high-aggregate challenges in mAb purification resulted in:

•        High monomer purity from 10% aggregate level feedstock
•        The removal of difficult host cell proteins (HCPs)
•         Increased productivity via flow-through operation (over bind-and-elute methods)
•         Expanded toolkit of mAb polish chromatography resins

Discover how you may enhance downstream mAb processes with guidance from this application note.