White paper: Approaches to alleviating subcutaneous pain at injection sites

    Feb. 20, 2024
    High concentration mAbs can create challenges for subcutaneous injection, namely pain at the injection site. This peer-reviewed article compares buffer formulation options, and an excipients selection strategy, in reducing injection-site pain.
    approaches_to_alleviating_subcutaneous_pain

    mAbs delivered via subcutaneous (SC) injection provide numerous patient benefits and are currently the most common route of self-administered drugs. Yet these therapies must be formulated at high concentration, which may cause increased injection-site pain.

    This article will discuss the use of citrate in SC formulations as compared to other buffers, as well as a formulation and excipients selection strategy that can be used to mitigate the risk of injection-site pain due to buffer, pH, and viscosity.

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