Microfluidics Inc.

Microfluidics will showcase two of its most popular laboratory fluid processors, the M-110Y and M-110EH Microfluidizer processors, in Booth # 1438 at Chem Show 2005, November 1-3 in New York, N.Y. The M-110Y (photo below) is a pneumatic bench top version, while the M-110EH (pictured above) is a plug-in electric-hydraulic floor model on wheels, rounding out a comprehensive line of lab machines for cell disruption, formulation development and other fluid processing applications. The M-110Y is an easily portable lab machine that provides an order of magnitude higher shear rate than any available fluid processor on the market today. The M-110Y processor maximizes the energy-per-unit fluid volume insuring the generation of uniform, submicron particle and droplet sizes. Process pressures are highly variable and reproducible, ranging from a low of 1,500 psi to a high of 23,000 psi. Options available for the M-110Y include a NIST traceable pressure transducer and thermocouple and accessories allowing pressurized sample feed.With process pressures ranging from 2,500 to 25,000 psi, the M-110EH processor maximizes the energy-per-unit fluid volume, resulting in uniform submicron particle and droplet sizes. Equipped with a single acting intensifier pump that amplifies the hydraulic pressure at the simple turn of a knob, the M-110EH drives the product through the interaction chamber at a constant pressure. Options available for the M-110EH processor include a small volume configuration capable of processing samples as small as 25 mL and an explosion-proof version for operation in hazardous environments.

Microfluidics' M-110Y

Both the M-110EH and the M-110Y Microfluidizer processors utilize proprietary interaction chambers that are specifically designed with fixed-geometry, wear-resistant micro channels that accelerate the product stream to high velocities. This process creates controlled and reproducible shear and impact forces that bring about the desired results. Because the interaction chamber employs no moving parts, no disassembly is required for cleaning.Both systems are capable of processing a wide variety of fluids ranging from simple oil-in-water emulsions to highly immiscible solids-in-liquid suspensions. This broad range of capabilities provides an extensive number of options for formulating new lead drug candidates, thereby hastening the drug development process. Additionally, each processor is easy to operate and designed for clean-in-place procedures. These features facilitate the use of these systems for cell disruption, virtually eliminating sample cross-contamination. Because each Microfluidics unit is process repeatable and scaleup is guaranteed, customers can be confident that their laboratory scale development efforts will scale to pilot and production volumes.