WMFTG Quantum Peristaltic Pump for Single-use Downstream Bioprocessing

May 18, 2017
The product aims to introduce a flow linearity with lowest pulse, a wide turndown with ultra-low shear, a simple to use single-use technology and easier validation.

The Watson-Marlow Fluid Technology Group (WMFTG) Quantum peristaltic pump with ReNu single-use (SU) cartridge technology aims to set the new standard for high-pressure feed pumps in SU tangential flow filtration (TFF), virus filtration (VF) and high-performance liquid chromatography (HPLC). According to WMFTG, Quantum represents a step-change in pump technology for bioprocessing by enabling higher downstream process yields throughout the pressure range, delivering virtually pulse free linear flow, lowest shear and easy validation aligned with Biophorum Operations Group (BPOG) guidelines.

Quantum delivers higher accuracy with flow linearity independent of back-pressure. Flow linearity is achieved across the 43.5 pound-force per square inch (psi) (3 bar) SU processing pressure range up to 5.3 gallons per minute (20 liters/minute), with trace pulsation of only ± 1.74 psi (±0.12 bar).

The pump is also ultra-low shear. An integrated 4000:1 speed control ratio allows users to sustain constant transmembrane pressure in micro and ultrafiltration. The user interface is located at the front of the pump, enabling visual confirmation of operating state and access to pump controls even when skid mounted.

The ReNu SU technology cartridge is said to enable its aseptic fluid paths to be positioned quickly. The ReNu SU Technology cartridge slides into position, allowing for a change of fluid path in minutes while eliminating alignment errors.

Quantum’s ReNu SU cartridge offers validation and extractable data in line with BPOG, Bio-Process Systems Alliance (BPSA), United States Pharmacopoeia (USP), and International Organization for Standardization (ISO) guidelines. Suitable for gamma irradiation up to 50 kilogray (kGy), ReNu SU is manufactured in an ISO Class 7 cleanroom, with all contact material tested for biocompatibility and BPOG-derived extractable studies. Available as a cartridge or as a component within a Watson-Marlow BioPure PureSU single-use fluid path assembly.