News of the latest pharmaceutical cureall for any pharma managers of the Chainsaw Al Dunlap variety: Deferred MaintenaXe. Write in if you have worked with, or know, senior managers who have become addicted to this drug and need to reduce their dosage (or try rehab). Here is a PPT that Joel Leonard and co. show, about Career Paths Not Taken, to promote their mission (which could easily be extended well beyond maintenance. ) I leave you with its a quote from its last page, very appropriate to drug manufacturing today (a reminder that not too many government officials (or their speechwriters) today are as eloquent as some of those in the past): "The society that scorns excellence in plumbing because plumbing is a humble activity, and tolerates shoddiness in philosophy because philosophy is an exalted activity, will have neither good plumbing nor good philosophy, because neither its pipes nor its theories will hold water" -John Gardner (former HEW secretary). And now for a paraphrase for drug companies: "A drug company that scorns excellence in manufacturing because manufacturing is a humble activity and tolerates shoddiness in science and R&D because science and R&D are an exalted activity, may have great marketing but will have neither good science nor good manufacturing---its new R&D concepts won't be manufacturable, and its products won't be innovative..." Enough preaching. "Say goodnight Gracie," and so, good night.