Millipore Corp.

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Millipore Corp. on June 5 announced the availability of new Mobius disposable TFF (Tangential Flow Filtration) assemblies, offering flexible, self-contained solutions that reduce validation efforts, increase process speed and mitigate risks. Millipore’s Pellicon cassettes are used with the disposable TFF assemblies.

These assemblies are a complete, self-contained TFF flow path consisting of process container, tubing, connectors, and innovative disposable cassette manifolds that eliminate fluid contact from any reusable components. The disposable assembly can be integrated into a complete TFF system that includes in-line monitors, process pump, filter cassettes and holder, and optional controls and instrumentation. The assemblies are being showcased at the IBC Disposables for Biopharmaceutical Manufacturing conference, June 5-7 in La Jolla, Calif.

These assemblies are manufactured, assembled and validated prior to shipment, eliminating the need for customers to validate multiple products from multiple suppliers. Without sacrificing performance, the innovative disposable TFF system eliminates system and cassette cleaning, reduces downtime between production runs, minimizes validation efforts, costs and paperwork, and reduces development time, thus improving speed to market.

From preclinical to clinical to full-scale production, Millipore’s new Mobius TFF assemblies are optimized for concentration and diafiltration applications in processes such as gene medicines, monoclonal antibodies, therapeutic proteins and vaccines.

Millipore’s Mobius solutions include a suite of disposable technologies, such as filtration products, process containers, connectors, and valves, along with design, validation and support services to integrate and deliver a complete disposable solution.

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