Benzodiazepines and Degradants


This application note describes the use of the Charged Aerosol Detection (CAD) for the measurement of benzodiazepines, and illustrates its ability to simultaneously measure low level contaminants and breakdown products. The method has a limit of detection of ~5-10ng on column, shows good precision [%RSD (n=5) 0.6-1.2 (200ng on column), 0.4-0.9 (2μg on column)] and has a dynamic range from ng to μg levels.