Detection Selection for TOC Analysis: Analytical Considerations for Cleaning Validation and Purified Water Testing


The task of choosing a Total Organic Carbon (TOC) analyzer for cleaning validation and purified water testing brings one to consider the many techniques currently on the market. This becomes more difficult when faced with understanding that TOC analyzer manufacturers may use different detection techniques, which could affect the analytical data. This article highlights some analytical differences between the two major TOC detection techniques and offers suggestions for a process to base the choice upon the user’s unique needs. A comparison of two commonly used techniques, Non-Dispersive Infrared (NDIR) and Membrane Conductivity, will be given based on sample matrices.