Why Total Organic Carbon (TOC) is Often Superior To HPLC for Cleaning Validation Sample Analysis: A Real-world Example


This white paper discusses the application of TOC analysis to cleaning validation. Traditionally, single-assay techniques such as HPLC have been used for that purpose; however, the authors note that not only is TOC less expensive to implement and maintain, but its non-specificity also provides distinct informational advantages over qualitative techniques.