A Science-based Performance Comparison of On-line TOC Analyzers


Most pharma companies in the U.S. and Europe use laboratory total organic carbon (TOC) analyzers for the U.S. and European Pharmacopeia compendial TOC release of water to manufacturing in order to improve quality and lower the costs of producing purified water. The basis of a properly designed and qualified on-line TOC-based real-time release (RTR) system is to identify and understand the critical parameters for success. The study described in this white paper by GE Analytical Instruments focuses on the performance capabilities of pharmaceutical on-line TOC analyzers.