Detecting Compounds of Dissimilar Ionization Using Dual Source Ionization for Increased Throughput

Overview:

To achieve a rapid and thorough analysis of complex or unknown samples, it is imperative to develop a system that results in a high probability of detection. Since compounds preferentially ionize based on both polarity and ionization method, it is critical to develop techniques that support multiple methods. Traditional dedicated ionization sources, such as metabolic screening, can hinder high-throughput analysis by limiting the number of samples that can be examined within a set time frame. By combining electrospray and atmospheric pressure chemical ionization into a single run, instrument time can be halved, allowing for a greater number of samples to be analyzed.