Quantitative XRD: Detection of Low Amounts of Crystalline Impurities for Pharmaceutical Process Control


In this example application, standard samples of Form 1 of an API were spiked with low levels of the polymorph Form II. XRPD was used to calibrate an analysis, programmed in PANalytical's X'Pert Industry software, which could then be used for manufacturing process control to ensure that the right polymorph crystallized in the process steps.