Enhancing Protein Analysis with Mass Spectrometry in Pharmaceutical Development of Biotherapeutics


As the desire to bring more commercially successful biological therapeutics to market grows, the need to bring easier and more sophisticated analyses of these complex molecules also increases. In contrast to small molecules, many of the development, production, and QC issues surrounding biotherapeutics can be quite a bit more complicated due to the inherent complexity of the molecules. To help facilitate the development of biotherapeutics, Mass Spectrometry can be used as a powerful tool for all types of product analyses ranging from protein and peptide fingerprinting and sequencing, impurity and degradant identification, to analysis of post-translational modifications.