2008

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  • Handheld Raman Spectroscopy for Material Identity Verification

    TruScan is a rugged handheld system that uses Raman spectroscopy for rapid, accurate material identity verification, offering ease of operation in a tough, lightweight form. TruScan was designed to meet the stringent requirements of pharmaceutical and industrial manufacturing operations, particularly given increasing regulatory and liability pressures, variable batch sizes in more adaptive manufacturing environments, and the prevailing drive toward Lean manufacturing.

    Ahura Scientific, Inc.
    12/15/2008
  • Rapid Material Verification With Handheld Raman Spectroscopy

    For decades, analytical laboratories have used Raman spectroscopy for chemical identification. Raman is well-suited for pharmaceutical applications such as raw material verification due to extremely high molecular selectivity and the ability to sample through glass and plastic containers. With TruScan, Ahura Scientific has taken this proven technology and — for the first time — enabled Raman sampling to take place at the point of inspection. Advanced decision-making algorithms and an integrated workflow are combined in a rugged, miniaturized handheld Raman system for an ideal material verification instrument. This 4-page brochure details the capabilities and applications of Ahura's TruScan instrument.

    Ahura Scientific, Inc.
    12/15/2008
  • The Right Analytical Method For The Right Application: TOC Analysis For Cleaning Validation

    This paper investigates the advantages of using a non-specific method for cleaning validation over more traditional analytical methods such as HPLC. It also looks at TOC methods and shows how using Sievers TOC technology can result in greater resource productivity, improved yields, reduced equipment downtime, and a better bottom line.

    GE Analytical Instruments
    12/15/2008
  • Why Total Organic Carbon (TOC) is Often Superior To HPLC for Cleaning Validation Sample Analysis: A Real-world Example

    This white paper discusses the application of TOC analysis to cleaning validation. Traditionally, single-assay techniques such as HPLC have been used for that purpose; however, the authors note that not only is TOC less expensive to implement and maintain, but its non-specificity also provides distinct informational advantages over qualitative techniques.

    Will McHale, Brian Wallace and Steve Lawson
    12/15/2008
  • High Throughput Diffraction

    PANalytical's X'Pert PRO MPD, equipped with automated sample changer and high speed, high resolution X'Celerator detector can already measure hundreds of full scans every day with a range of additional tools, it provides a solution for high throughput XRD.

    PANalytical Inc.
    12/14/2008
  • TruScan: What Does Your Plant Spend on Raw Material ID? The Answer May Surprise You

    This paper contains valuable information for plant managers of pharmaceutical or contract manufacturing facilities. Learn how handheld, non-contact material ID technologies such as TruScan have enabled manufacturers to reduce production costs while simultaneously increasing productivity and decreasing risk. With TruScan’s ease of implementation, managers have experienced financial returns within months.

    Ahura Scientific, Inc.
    12/14/2008
  • Handheld Raman Spectrometer Facilitates Fast, Cost-effective Method Development

    This application note explains how Ahura's TruScan instrument may be used to speed method development. Due to Raman spectroscopy’s molecular selectivity and the intuitive design of TruScan's user interface, method creation is typically completed in a few simple steps through the instrument's Web-based administrative tool.

    Ahura Scientific, Inc.
    12/14/2008
  • Characterizing and Validating Handheld Raman Instrument Discovery Library Performance

    Traditional analytical figures of measuring qualitative performance are unsuitable for characterizing identification of unknowns. However, ROC curves and precision characteristics represent a promising means to measure spectroscopic discovery library performance. This application note discusses how Ahura Scientific's handheld Raman devices are able to accurately and precisely identify an unknown material.

    Ahura Scientific, Inc.
    12/14/2008
  • Introduction to Raman spectroscopy: Pharmaceutical Applications

    While there is no one technology that is right for all applications, Raman spectroscopy is gaining favor as a quality control tool due to gains in economy, speed and sensitivity that have accompanied modern electronic and laser production. Instruments that once cost $200,000 and required specialized users are now available for less than $50,000 with decision making software that enables non-technical personnel to be proficient users. Instruments once relegated to high overhead laboratory space can now be carried with one hand to a production room or receiving area. The ability of Raman to measure through containers and be independent of environmental humidity make it an ideal technology for compendial

    Ahura Scientific, Inc.
    12/14/2008
  • MSN Analysis of Natural Nutraceutical Supplements

    Over the past 5 years, a rising trend in the use of over-the-counter alternative/complementary medicine has lead to a sharp growth in the global nutraceutical market. A recent herbal supplements market report estimated a 1.7% average annual growth rate from $5.5 billion in 2005 to $6.1 billion projected for 2011. This is highlighted by the widespread increase in the regular personal use of natural health supplements such as red fruit anthocyanins, green-tea and ginseng. Typically, electrospray techniques have been used in the analysis of these products. In this white paper, Shimadzu investigates the use of MALDI-QIT- TOF-MS in the identification and structural elucidation of biologically active ingredients in red fruit/vegetables, green-tea and ginseng; comparing and contrasting these results with those obtained using ESI-IT-TOF-MS.

    Shimadzu Scientific Instruments
    12/12/2008
  • High-accuracy Measurement of TOC below 5 PBB Levels

    The current regulatory demands of the industry require analytical instruments that can measure at increasingly lower detection limits with high precision and accuracy. For example, some ultrapure applications in TOC require trace level detection to ensure highly accurate and precise results. The Shimadzu Wet Chemical TOC-VW is the only TOC analyzer on the market that offers three oxidation techniques — UV light, persulfate, and heat — in a single instrument. This allows for optimal TOC sensitivity with a method detection limit of 0.5 ppb. This application note demonstrates how the TOC-VW meets the demands of ultrapure applications by achieving practical quantitation below 5 ppb.

    Shimadzu Scientific Instruments
    12/12/2008
  • How New Advances in FTIR Sampling Technology Can Make Your Life Easier

    FTIR has become a more useful tool in the past 20-25 years. Several companies these days not only supply FTIR accessories, but also depend on maintaining state-of-the-art design to serve their customers. These organizations, as well as many of the FTIR manufacturers, have been at the forefront of this technology. This white paper the evolution of Attenuated Total Reflectance (ATR) as a significant development for FITR.

    Shimadzu Scientific Instruments
    12/12/2008
  • Achieving Ultra fast Liquid Chromatography (UFLC)

    Today’s demand for increased efficiency in the analytical industry has highlighted the important technical challenge of providing faster separation in HPLC. This paper describes various approaches to achieving faster separation and explains how combining Shimadzu's Prominence UFLC components with XR-ODS columns enables users to shorten analysis time dramatically without extremely high pressure, while maintaining the high separation efficiency of conventional columns.

    Shimadzu Scientific Instruments
    12/12/2008
  • Achieving Ultra Fast Liquid Chromatography

    The demand for increased efficiency and speed in pharmaceutical analysis extends through drug discovery and development to clinical screening and trials. The need to meet these throughput requirements without compromising the data has highlighted the important technical challenge of providing faster separation in HPLC.

    Shimadzu Scientific Instruments
    12/12/2008
  • Analysis of Basic Drugs by Column-switching Liquid Chromatography-mass Spectrometry

    Sample throughput in LC/MS analysis is often limited by complex sample preparation methods designed to maximize the selectivity and sensitivity of detection without the constraints of matrix effects. Recent approaches to the acceleration of method development and reduction of analysis times have involved column-switching LC systems in which the first column eliminates macromolecular compounds such as proteins from plasma samples, and is followed by a second column that is used for analytical separations. This white paper describes the analysis of tricyclic antidepressants (doxepin, desipramine, imipramine, nortriptyline, amitriptyline and clomipramine) by LC/MS using the MC-SCX.

    Shimadzu Scientific Instruments
    12/12/2008
  • Balances: AU, UW/UX, by Shimadzu Scientific Instruments

    Shimadzu balances and scales offer features such as temperature-activated calibration, OIML and NIST-traceable standards and high-speed analysis. Products include analytical and micro-balances, top loading balances, precision platform scales and moisture balances. The AU and UW/UX series of toploading balances utilize the patented Shimadzu UniBloc sensor to achieve high performance, fast response and durability. Available features include multiple units of measure, piece counting, checkweighing functions, auto print and GLP/GMP/ISO output including date and time data from a built-in clock. The new series also feature Shimadzu's Windows Direct communication, requiring no software installation to quickly integrate balances with lab or business software.

    Shimadzu Scientific Instruments
    12/12/2008
  • AUW-D/AUW/AUX/AUY UniBloc Analytical Balances

    Shimadzu Scientific Instrument's AUW-D dual range five-decimal balances measure in compliance with GLP/GMP/ISO9000 and offer an automatic span calibration. The balances boast user-friendly qualities and convenient application support.

    Shimadzu Scientific Instruments
    12/12/2008
  • Fact or Fiction: Automated Dissolution Testing Reduces Operator Error and Increases Overall Efficiency

    While the automation of dissolution testing is primarily touted as a means to reduce operator bench time, the reduction in operator error is often overlooked. In fact, many pessimists argue that the calibration and service hours associated with automation negate the overall reduction in operator bench hours. The proper way to view the overall picture is to include a measure of the quality of the data obtained by the manual and automated methodologies along with the difference in bench hours. Operator-induced error occurs at two points during a UV-Vis based dissolution test: (1) when sampling from the dissolution vessel and (2) during the spectroscopic analysis. Both sources of error are due to variations in the technique of the bench chemist. Although the testing performed for these simple studies was relatively small, it has indicated whether induced variance has an effect on a seemingly sensitive pharmaceutical product, the USP 10-mg Prednisone dissolution calibrator tablet. The studies discussed in this white paper showed that whereas automated dissolution testing did not improve the accuracy or precision of the results, it did boost overall efficiency (in that it reduced the time required for analysis).

    Shimadzu Scientific Instruments
    12/12/2008
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