ESA Biosciences Knowledge Center

 
ESA Biosciences Knowledge Center
ESA Biosciences provides novel products and services with an understanding of the scientific needs of customers and 40-year expertise in small molecule and biomolecule detection. We design and manufacture specialty HPLC detectors, including the Corona charged aerosol detector and Coulochem III and CoulArray electrochemical detectors; HPLC instruments, reagents, consumables; as well as turnkey systems that scientists need to achieve maximum performance. ESA – a Dionex Company is a full service, ISO-certified and FDA-registered supplier to the pharmaceutical and life science industries.

Quick Facts

  • ESA - A Dionex Company
  • 22 Alpha Rd
  • Chelmsford, Mass. 01824
  • USA

Table of Contents

Webcasts

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Video

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White Papers

Real-Time Release: It’s Time for Action, Not Debate

Before arguing about Just in Time (JIT) solutions and how to define them, shouldn’t we look at why we need them, and form a plan?

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Therapeutic Dose: Good Enough is Not Good Enough

As mom used to say on my report card: you could do better.

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PharmaView: CEOs: Head Cases?

For CEOs, maybe therapy comes with the territory.

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Application Notes

Funny Pharm: You Write the Caption & Win: April 2011

Introducing "Funny Pharm," sponsored by Paratherm Corp., featuring drawings by award-winning cartoonist Jerry King. Submit your caption and win.

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NIR Calibration Transfer

A practical approach can allow to applying multivariate analysis to calculate calibrations for multiple analyzers in a network.

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Grasping Lyophilization Product and Process Parameters for Biopharma

A clear understanding of product and process parameters is essential if freeze drying is not to remain a “trial and error” process. This excerpt from an authoritative book* summarizes the basics.

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Bridging the Gap

Despite talk of IT and process control convergence, the two functions are still disconnected, from each other and from manufacturing, at many pharmaceutical companies today.

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CAPAS: Too Much or Not Enough?

A strategic CAPA plan requires transparent information and a clear understanding of root causes.

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Focusing on Phase 0

Materials characterization and the principles of manufacturability are guiding a Florida-based contract research and manufacturing company.

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Therapeutic Dose: Extending QbD to Stability Testing

The concept of a process signature can easily be extended to stability testing.

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Funny Pharm: You Write the Caption & Win: March-April 2011

Introducing "Funny Pharm," sponsored by Paratherm Corp., featuring drawings by award-winning cartoonist Jerry King. Submit your caption and win.

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Products

New UHPLC Detector: Corona Ultra

The new charged aerosol detector that is now truly UHPLC compatible. With reduced peak dispersion and 100 Hz acquisition rate, this detector is suited for diverse applications from small molecules and carbohydrates to lipids and polymers. With 1 second peak widths at base at 0.2 – 2 mL/min and run times at least 5 times faster than conventional systems, the Corona ultra delivers reduced time for method development, increased throughput and approximately 5 times lower solvent consumption. Typical sensitivity of <10ng on column and even as low as ~ 500 pg on column for carbohydrates make the Corona ultra the first choice for analytical R&D through manufacturing QC.

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Case Studies

From the Editor: Guiding the Invisible Hand

Drug shortages kill patients every day, right here in the U.S. It’s time for creative, market-based solutions.

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The Supply Chain: Where Push and Pull Are Friends

For supply chain success, abandon dogma and seek a hybrid approach. McKinsey & Co.'s Knut Alicke, Christoph Karrer and Ulf Schrader explain.

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From the Editor: Lurching Toward Agility

Agility won’t come overnight, but we’re already catching glimpses of the pharmaceutical facility of the future

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Pharma Facilities: Can One Patent Agility?

A facility design under development for a decade is now gaining appreciation.

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