Flexibility by Design

For continuous processing or efficient pharma process expansion, gas-handling-system flexibility holds the trump card

By Larry Gallagher, Specialty Gas Products Manager, Concoa

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Designing and specifying gas-handling systems that are as expandable as a child’s LEGO set is today a reality, thanks to innovative systems designed with flexibility in mind. Whether one is expanding research and development facilities, ramping up production for late-stage clinical trials or moving to full-scale production, the more modular, reconfigurable and flexible gas-handling systems there are, the better.

By using switchovers, manifolds and similar technologies, systems can start small and expand as need and frequency progress in moving from cylinders to dewars and microbulk, without having to replace original equipment.

In so doing, processes are continuous and efficient, and savings are indeed measurable. 
solutionsFigure 1. Incorporating a protocol switchover station into a gas delivery system is a simple way to connect multiple cylinders to a common supply line.

Manifolds allow the connection of multiple cylinders or containers of the same gas to a common supply line that is then delivered to the pressure control device or process. This can be as simple as two cylinders connected to a pressure regulator using flexible hose assemblies as in a protocol switchover station, (see figure 1), or as complex as a fully automatic switchover that can interface with remote alarms, building management systems, or even send email alerts when cylinders need replenishment (see figure 2).

Though it may seem simple enough to increase the available gas on hand for almost any instrument or process, the design and functions of needed equipment are dictated by the specific process and gas involved. Where possible, the system should be able to expand and accommodate the addition of more cylinders without the need to shut down the process. A flexible, expandable manifold design might feature diaphragm isolation valves for leak integrity and positive closure and modular metal-to-metal seals that allow for system expansion. Additionally, system designers should select high-quality materials, (preferably 316L stainless steel) for diaphragms and for appropriately rated flexible hose assemblies. Hose assemblies should also be specified with integral check valves to prevent cylinder backfilling and reduce system exposure to ambient air. 


Sizing Does Matter
As for the available gas connected to a particular system, it should be sized so one side of the system has enough gas to last for a minimum of one- to two-weeks’ use. Deploying a modularly designed cylinder header system assures process system planners that, as instruments are added and more cylinders are required to meet required demand, the system will remain easily expandable by simply adding additional pigtails to auxiliary ports or by attaching extensions that add more stations, as shown in figure 3. 

When it comes to the purity requirements of today’s process analytical technologies, such as gas chromatographs (GCs), or inductively coupled plasma mass spectrometers (ICP MS), the gases must be at least 99.999% pure or better. Typically for GC carrier gases like helium, the only supply option source is from high-pressure gas cylinders or pallets of high-pressure cylinders. The manifold best suited for this type of application traditionally is one capable of a differential pressure switchover in which the switching pressure and resulting residual gas left in the cylinders could be as high as 200 psig over the required line pressure. 

While it is impossible (and not desirable) to deplete cylinders to below approximately 150 psig — because of pressure drop in long pipelines — there is also the risk of impurities, particularly moisture, that may increase at lower residual pressures in the cylinders. With the increasing cost-per-cylinder of high-purity helium, the ability to easily change switching pressure can be cost-effective. Achieving this goal can only be accomplished with a system in which the switching pressure is determined by an electronic or computer-controlled input value, one that can be programmed to switch at as low a pressure as realistically possible. For example, if the setpoint allows the switching pressure to be reduced by 100 psig, the helium cost savings can add up to as much as 5% per year.  

For gases including nitrogen, argon, oxygen or carbon dioxide in which the initial source is from high-pressure cylinders, there are alternative supply sources that become more attractive as the volume of gas needed increases.

These gases, for example, can be supplied in a cryogenic form delivered in insulated portable dewars that hold up to the equivalent of 18 high-pressure cylinders. Such gases can also be delivered to small stationary cryogenic micro-bulk tanks that are filled on-site, able to contain three times the volume. The benefit, particularly for nitrogen and argon delivered in cryogenic form, is higher purity; in most cases, equal to that of high-purity cylinder grades at a fraction of the cost. 

Luckily, there are systems available now that not only can be used with high-pressure cylinders when a particular need demands it — say argon to feed an ICP MS is for only one instrument — but also can be used with cryogenic sources by simply pushing a button that configures the system for the lower pressures found in cryogenic delivery forms.

However, there are two pitfalls that can reduce the cost savings potential of gases supplied in cryogenic form. First, any container that is not in use will build pressure to a level in which the dewar or micro-bulk pressure relief device actuates. Under these circumstances, the container may vent between 2 - 3% of its contents per day. That can mean that 10% to as much as 15% of the product will be wasted, also known as evaporation loss. Fortunately, there are systems that manage either cryogenic or high-pressure sources that incorporate an economizer feature (see figure 3) that senses when the container not in use is about to start to vent and automatically switches to supply the end-use points from that container, reducing pressure and avoiding venting.

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