Topic: Unit Operations

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On Shire, Single-Use and Simplicity
CRB’s Eric Unrau talks about what worked at Shire Lexington, and what limitations need to be oversome for single-use systems.

Capacitive Humidity Sensors: Advantages and Disadvantages
Winston Churchill reportedly said, “Democracy is the worst form of government, except for all the others.” So it is with capacitive humidity sensors. These sensors can perform amazingly well in some environments and terribly in others.

Design Considerations and Best Practices for Tank Vent Filtration
Understanding the diverse applications of vent filters is critical to their proper implementation and use.

Transforming Data into Information: An Engineering Approach
A standardized, recipe-based approach adds value and turns data into actionable knowledge.

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White Papers: In Depth Research

The Safest Way to Calibrate: An Introduction to Intrinsically Safe Calibration
Author: Beamex
Posted: 02/07/2011
Intrinsically safe calibrators are not only the safest possible calibration equipment—used even for Zone 0 environments—but also provide the functionality and performance of regular industrial calibration devices. This paper provides a primer on the meaning and benefits of intrinsically safe calibration, as well as details on Beamex multifunction calibrators.

Turning Data Into Information: Making Sense of an Avalanche of Supply Chain and Production Data
Author: Bio-G
Posted: 01/28/2011
Biomanufacturing and operations research experts describe how to deal with staggering volumes of production and supply chain data. Learn how to convert this data into actionable information, which will be of value to the whole organization. Read about consolidating data from disparate sources, paramaterizing and visualizing data, building models for analysis and better decision making and a "complete systems" based approach to data consolidation, visualization and analysis.

Zeta Plus Activated Carbon Cartridges Evaluation & Scale-Up for Pharmaceutical Applications
Author: 3M Purification Inc.
Posted: 05/17/2010
This Technical Brief describes how the Zeta Plus Activated Carbon Cartridge series is evaluated for use in pharmaceutical applications and how the optimal carbon type and media grade are chosen for a given application. In addition, the brief describes how a process is scaled-up in order to determine the requisite Zeta Plus Activated Carbon filter area for manufacturing and production of an active pharmaceutical ingredient.

Increasing Tablet Press Productivity Using Segmented Turret Technology
Author: Fette America
Posted: 04/15/2010
Surveys of tablet press users reveal that machines with segmented turrets increase output and reduce set-up and cleaning time over conventional presses and previous turret technologies. This paper will discuss survey data from drug manufacturers using the technology and quantify some of the benefits over conventional press technologies.

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