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Developing a Process Control Model for Mammalian Cell Culture Production

Process development groups use modeling to improve the predictability of bioprocesses. Broadley-James Corp. and partners (Nova Biomedical, Emerson, Thermo Fisher, and others) are working to establish “black box” models—first for recombinant proteins and now for mammalian cell culture—that investigate control strategies to better inform process experimentation. Broadley-James’ Michael Boudreau explains.