Articles

Powder Flow: Identifying Powder’s Critical Quality Attributes & Relationship to Process Behavior

Powders are highly complex variable materials and are used in the manufacture of over 80% of products currently on the market. Flow properties relate to numerous processes so powder behaviour will influence all sorts of key quality attributes of the finished product.
Post Date: 04/29/2013
Author:

Calibration for Compliance

This Fundamentals Series presentation covers calibration and its importance to pharmaceutical manufacturers, how to handle changing procedures and standards, creating a chain of traceability and calibration guidelines and more.
Post Date: 03/06/2013
Author:

Quantifying Humidity's Impact on Powder Processing

Dynamic test methods assess moisture to improve process understanding and development
Post Date: 02/05/2013
Author: Jamie Clayton and Brian Armstrong, Freeman Technology

Fundamentals Series: Dusts: Understanding and Managing the Risk

This Fundamentals Series presentation includes how a dust can become an exposure, risk outlined, regulatory guidance update/clarification, powder behavior/material migration, setting occupational risk limits, protective apparel best practices, setting occupational risk limits and types of exposure dust.
Post Date: 02/03/2013
Author:

Portable Raman for Raw Material QC: What’s the ROI?

Hand-held spectrometers can save laboratory costs while improving traceability
Post Date: 01/15/2013
Author: Dr. Enrique Lozano Diz and Robert Thomas, B&W Tek

Measuring Water Vapor in Tablet Coating

Devices for measuring water vapor in process applications are often different from those used in environmental conditions.
Post Date: 01/15/2013
Author: Jim Tennermann, Life Science Segment Manager, Vaisala

Tools to Keep Pharma Fluids Flowing

An assortment of pump and valve innovations help provide clean process efficiencies.
Post Date: 01/15/2013
Author: Katie Weiler, Managing Editor

Cold Chain Fundamentals: A Cornerstone of Manufacturing and Supply Chain Excellence

This Fundamentals Series presentation offers an overview of the cold chain, addresses responsibilities, regulations, risks and pitfalls of the cold chain, discusses storage and transportation of temperature sensitive materials, outlines factors critical to success, provides numerous guidance and regulatory resources.
Post Date: 01/14/2013
Author:

Troubleshooting Tableting

Anything from excess moisture to variable API loading can affect tablet quality. PAT methods and equipment innovations can reduce variability.
Post Date: 01/07/2013
Author: Agnes Shanley, Editor in Chief

Building Strengths in Healthcare Supply Chain

As operations become more complex, even small improvements in efficiency can translate into huge savings
Post Date: 11/07/2012
Author: Thomas Ebel, Katy George, Erik Larsen and Ketan Shah

Water Vapor Measurements for Non-Environmental Applications

Devices for measuring water vapor in process applications are often different from those used to measure environmental conditions, and RH might not be the best parameter to express the amount of water vapor in a gas. Vaisala's Tennermann explains.
Post Date: 10/31/2012
Author: Jim Tennermann, Life Science Segment Manager, Vaisala

Trouble Shooting Depth Filtration

Some common scenarios (and their root causes)
Post Date: 10/03/2012
Author: Brittany Nixon, 3M Purification

Estimating Risk-Based Cost and Contingency

How to Apply Monte Carlo Simulation to Engineering Capital Projects
Post Date: 09/05/2012
Author: Keith Melchiors

Soaring Innovation, Grounded Goals

Readers recognize tools that break new ground but promise to improve efficiency
Post Date: 08/15/2012
Author: Paul Thomas, Senior Editor

A New Era in Handheld Raman Devices for Pharmaceutical Applications

FDA’s John Kauffman describes the vast potential of portable Raman devices, even for those who are not trained spectroscopy experts.
Post Date: 06/27/2012
Author: Paul Thomas, Senior Editor

Pharma Sustainability Is on a Roll

Drug industry environmental stewardship projects are becoming more sophisticated and challenging. Here are examples from AstraZeneca, Bayer, DSM, Pfizer, and EMD Millipore
Post Date: 05/16/2012
Author: Paul Thomas, Senior Editor

EMD Millipore: Giving and Receiving Single-Use Systems

A talk with sustainability manager Johanna Jobin about the company's new product recycling initiative.
Post Date: 05/16/2012
Author: Paul Thomas, Senior Editor

Sartorius and G-Con: Bioprocess Cleanrooms Go Mobile

A joint collaboration claims it has a “disruptive technology” that can be shipped anywhere, and used in any way. Does it raise the bar for future flexible facilities?
Post Date: 05/08/2012
Author: Paul Thomas, Senior Editor

Environmental Control for Fluid Bed Machines

Perfecting the timing and precision of the moisturizing and drying procedures can eliminate or at least drastically reduce coating problems.
Post Date: 05/02/2012
Author: Michael Wetzel, P.E.

Implementing Disposable Cleanroom Apparel into the Manufacturing Process

In the case of disposable cleanroom apparel the benefits can include an easier gowning process, elimination of variability in filtration performance that can result from reusing apparel, less waste and improved levels of contamination control.
Post Date: 05/02/2012
Author: Damon Larkin, Category Manager at Kimberly-Clark Professional