The mixing of biological products is delicate business, but concerns about shear sensitivity can be overblown. Rational process development, rules of thumb and tools like CFD can lead to fearless mixing.
Author: Thomas A. Post, Ph.D., Consultant, Post Mixing Optimization and Solutions
Filtration can be the quickest, most cost-effective means to achieve sterilization for large volumes of simple buffers or aqueous solutions. However, finding the right flow rate and filter sizing is essential to meeting FDAs aseptic guidelines.